NAME

       mssstest  -  Normalisationo  of  disease  scores  -  originally developed for the EDSS for
       Multiple Sclerosis

SYNOPSIS

       mssstest

DESCRIPTION

       Suppose one is interested in determining whether the genotype at some  locus  of  interest
       affects  the  rate  of  progression of disease of people with Multiple Sclerosis (MS). One
       method would be to calculate the mean EDSS score in patients with each  of  the  genotypes
       and  test whether they are significantly different.  However, this approach is inefficient
       if patients have their EDSS assessed at different durations of disease,  as  patients  who
       have  had  MS  longer  typically  have higher EDSS scores regardless of their genotype. By
       adjusting for duration, a more powerful test can be developed.
       MSSStest is a program for implementing the method described in the  article  The  Multiple
       Sclerosis Severity Score. R. Roxburgh S. Seaman et al. (2004), accepted for publication by
       Neurology. It calculates MSSS scores and uses these scores to test for differences between
       disease progression rates in different groups defined by genotype at some locus.
       To  use  the  program first copy the table of disease scores to the current directory. You
       are expected to use the EDSS scores provided by the authors.

OPTIONS

       The program does not accept options, it should, though.  The  output  goes  to  the  files
       "msss.out" and "indivmsss.out".

SEE ALSO

       http://www-gene.cimr.cam.ac.uk/MSgenetics/GAMES/MSSS/#top
       /usr/share/doc/mssstest/README.gz

AUTHOR

       mssstest was written by Shaun Seaman and Richard Roxburgh <Richard@Roxburgh.net.nz>.

       This  manual  page  was  written  by Steffen Moeller <moeller@pzr.uni-rostock.de>, for the
       Debian project (but may be used by others).

                                        November 30, 2004                             MSSSTEST(1)