NAME

       THESIAS - Testing Haplotype Effects In Association Studies

DESCRIPTION

       The  objectif  of the THESIAS program is to performed haplotype-based association analysis
       in unrelated individuals. This program is based on the maximum likelihood model  described
       in  Tregouet  et  al.  2002  (Hum  Mol  Genet 2002,11: 2015-2023) and is linked to the SEM
       algorithm (Tregouet et al. Ann  Hum  Genet  2004,68:  165-177).   THESIAS  allows  one  to
       simultaneous  estimate  haplotype frequencies and their associate effects on the phenotype
       of interest.  In  this  new  THESIAS  release,  quantitative,  qualitative  (logistic  and
       matched-pair  analysis),  categorical  and  survival  outcomes  can  be  studied. X-linked
       haplotype analysis is also feasible.  Covariate-adjusted  haplotype  effects  as  well  as
       haplotype x covariate interactions can also be investigated.

AUTHOR

       THESIAS was written by David-Alexandre Trégouët.