Provided by: simrisc_15.05.00-1build1_amd64 bug

NAME

       simriscparams - The description of the  configuration files

DESCRIPTION

       This  page describes the organization of the simrisc configuration files.  These files are
       formatted like standard unix configuration files. Lines  are  interpreted  after  removing
       initial  white-space  (blanks  and  tabs)  and  after  removing  all characters from lines
       starting at the first # character: this is considered comment and is ignored.  If  a  line
       (not  containing  a  #  character)  ends  in  a backslash (\), then the next line (initial
       white-space removed) is appended to the current line.

       Note that all parameter identifiers are interpreted case sensitively. E.g.,  Costs:  is  a
       different  parameter  than  costs:.  The  numeric  values  used  in  this man-page are for
       illustration purpose only. Some restrictions apply though: standard deviations  cannot  be
       negative; proportions and probabilities must lie in the range 0..1; multiple probabilities
       (like the ones used for breast densities) must add up to 1;  etc.  If  restrictions  apply
       then they are mentioned at the various parameter descriptions below.

DEFAULT CONFIGURATION FILE

       The configuration file provided in the simrisc distribution is
       /usr/share/doc/simrisc/simrisc.gz.

       Usually this file is unzipped by the user to the user’s ~/.config directory:

           gunzip < /usr/share/doc/simrisc/simrisc.gz > ~/.config/

       whereafter ~/.config/simrisc can be edited to contain local modifications.

       Various  parameters  specify probability distributions. Usually the Normal distribution is
       specified. The program also recognizes the LogNormal and Uniform distributions,  and  uses
       the  Beta  distribution  when handling parameter variations of the beta parameter used for
       lung cancer simulations (note that the similarity of the names beta  (the  parameter)  and
       Beta (the distribution) is sheer accidentally).

       Parameter  specifications  start  with  keywords,  followed  by  a colon. All keywords are
       covered below. The format of the specifications is fixed, but empty lines and white  space
       may be used to improve the specifications’ readabilities.

       Parameter   specifications  starting  with  uppercase  letters  (like  Scenario:)  specify
       (sub)sections and contain  no  additional  specifications.  Specifications  starting  with
       lowercase letters (like ageGroup:) are followed by actual parameter values.

       The  configuration  file  must  define  all  parameters of all configuration sections, but
       configuration parameters can be modified using a separate analysis file  or  they  can  be
       modified by command-line parameters.

Section `Scenario:’

       This  section  starts  with  a  line  containing  Scenario:  and  it  defines some general
       parameters that are used during the simulation process.  The  default  configuration  file
       contains the following specifications:

       o      spread: false
              when specified as true parameter spreading is used;

       o      iterations:  1
              the (positive) number of iterations used in a simulation loop;

       o      generator: fixed
              in addition to fixed the modes random and increasing are available.
              This   parameter  specificies  the  way  simrisc’s  random  number  generators  are
              initialized. When mode fixed is used the random number generators  are  initialized
              with  seed’s  value;  mode  random  results  in  the random number generators being
              initialized by  randomly  selected  seeds  and  seed  (below)  is  not  used;  mode
              increasing  results  in incrementing the seeds of the random number generators by a
              fixed increment at each iteration;

       o      seed: 1
              the (positive) value to seed the random number generator with.  This  parameter  is
              ignored when generator: random was specified;

       o      cases: 1000
              the (positive) number of cases being simulated;

       o      death: ...
              the  death:  parameter may either be followed by the path to a file (if its initial
              character is a tilde (~) it is replaced by the user’s home  directory;  if  it’s  a
              plus  (+)  it  is replaced by the base directory (specified with the --base option,
              see the simrisc(1) man-page)), or it must  be  followed  by  101  cumulative  death
              proportions, where each line starts with <nr>:, where <nr> is the next order number
              to read. The default configuration file specifies:

                 death:
                    1: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000
                   11: .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000 .00000
                   21: .00000 .00014 .00028 .00042 .00056 .00070 .00106 .00142 .00178 .00214
                   31: .00250 .00382 .00514 .00646 .00778 .00910 .01118 .01326 .01534 .01742
                   41: .01950 .02312 .02674 .03036 .03398 .03760 .04414 .05068 .05722 .06376
                   51: .07030 .07776 .08522 .09268 .10014 .10760 .11564 .12368 .13172 .13976
                   61: .14780 .15718 .16656 .17594 .18532 .19470 .20658 .21846 .23034 .24222
                   71: .25410 .27560 .29710 .31860 .34010 .36160 .39368 .42576 .45784 .48992
                   81: .52200 .56240 .60280 .64320 .68360 .72400 .75826 .79252 .82678 .86104
                   91: .89530 .90962 .92394 .93826 .95258 .96690 .97104 .97518 .97932 .98346
                  101: .98760

              which are the 101 cumulative death proportions used for breast cancer simulations.

              If the 101 cumulative death proportions are available in, e.g., the user’s .config/
              directory as the file cumdeath then the specification could have been:

                  death:  ~/.config/cumdeath

              which  might  be convenient when using different values in Analysis: specifications
              (see section ANALYSES in the simrisc(1) man-page).

Section `Costs:’

       This section starts with a line containing Costs: and it defines several  parameters  used
       for   cost-calculations.  Modality-specific  cost  parameters  are  specified  at  Section
       Modalities: (see below). The default configuration file specifies:

       o      biop: 176
              the (positive) cost of performing a biopsy;

       o      diameters: 0: 6438  20: 7128  50: 7701
              pairs of diameter: cost values  specifying  the  treatment  cost  starting  at  the
              specified  tumor  diameter,  up  to  the next pair’s diameter (if specified) or all
              diameters starting at the diameter specified at the last pair. The  first  diameter
              must  be  0.  The  second value of each pair specifies the (non-negative) treatment
              costs for that age-group.

       o      Discount:
              the costs discount proportion starting at some age. This line is  followed  by  two
              additional  lines: the line discount: contains two values specifying, respectively,
              the discount proportions for breast- and lung-cancer  simulations;  the  line  age:
              specifies the discount’s starting age (for both simulation types):

                  Discount:       # breast    lung
                      proportion:      0      .04
                      age: 50

Section `BreastDensities:’

       This  section  starts  with  a  line  containing  BreastDensities:  which  are  used  with
       breast-cancer simulations. It defines  breast  density  values  for  various  age  groups,
       covering  ages  0  through  the maximum age for simulated cases. The default configuration
       file contains the following specifications:

           #                  bi-rad:  a       b       c       d
           ageGroup:  0  - 40         0.05    0.30    0.48    0.17
           ageGroup:  40 - 50         0.06    0.34    0.47    0.13
           ageGroup:  50 - 60         0.08    0.50    0.37    0.05
           ageGroup:  60 - 70         0.15    0.53    0.29    0.03
           ageGroup:  70 - *          0.18    0.54    0.26    0.02

       Age groups are half-open ranges: starting at their first ages, and end at (not  including)
       their  second  ages.  The  first ages of subsequent age groups must be equal to the second
       ages of their previous age groups. For the last age group the specification * can be used,
       indicating  that  all  ages at or above the last age group’s begin age are handled by that
       group.
       For each age group the probabilities of the four bi-rad classifications must sum to 1.0.

Section Modalities:

       This section starts with a line containing Modalities: and  it  specifies  cancer-scanning
       modalities.  Currently  three  modalities  are supported: Mammo, Tomo, MRI (which are used
       with breast-cancer simulations), and CT (which is used with lung-cancer simulations).

       Some  modalities  specify  age  groups,  which  are  (like  the  age   ranges   used   for
       breastDensities)  half-open  ranges:  they  start  at  their  first  ages, and end at (not
       including) their second-ages, while subsequent age ranges must connect. Also, the last age
       group may use the end-age specification *.

       The  default  configuration  file  contains  (below  the  line  Modalities:) the following
       specifications (if modalities aren’t used their specifications are optional):

       o      CT:
              The CT modality is used when performing  lung  cancer  simulations.  The  screening
              costs  are  used instead of the value configured at the Costs: biop: specification.
              The diagnosis: costs specifies the costs of performing a CT-scan.  The  M0  and  M1
              values specify the costs when, respectively, no metastatis or a matastasis has been
              detected.

              The radiation dose of CT scans is configured at the CT:  dose:  specification.  The
              sensitivity  depends on the tumor diameter. For tumor sizes between 3 and 5 mm. the
              sensitivity is computed using the formula (.5 * diameter - 1..5) * 100  (e.g.,  50%
              for tumors of 4 mm.)

              The default configuration file contains the following CT specifications:

                  CT:
                      #        screening    diagnosis    M0      M1   (M0, M1: Table S3)
                      costs:      176         1908      37909   56556

                      dose:  1

                      #               diam.   value (must be integral 0..100 or -1)
                      sensitivity:    0 - 3:  0
                      sensitivity:    3 - 5:  -1  # formula: (.5 * diam - 1.5) * 100
                      sensitivity:    5 - *:  100

                      #               mean    stddev  dist
                      specificity:    .992    .076    Normal

       o      Mammo:
              For  the  Mammo modality the costs, radiation doses and m: parameter specifications
              per bi-rad category, specificity probabilities for age groups,  the  parameters  of
              the beta-function, and the systematic error probability must be specified.
              The  Mammo sensitivity is computed using the beta-function published by Isheden and
              Humphreys (2017, Statistical Methods in Medical Research, 28(3), 681-702).  From  a
              randomly  generated  probability  and  the case’s age the case’s bi-rad category is
              determined and that category is then used to select the m-parameter that is used in
              the beta-function.
              The default configuration file contains the following Mammo specifications:

                  Mammo:
                      costs:          64

                      #      bi-rad:  a       b       c       d
                      dose:           3       3       3       3
                      m:             .136    .136    .136    .136

                      #             ageGroup
                      specificity:  0 - 40:  .961     40 - *: .965

                      #       1       2       3        4
                      beta:  -4.38    .49     -1.34    -7.18

                      systematicError:  0.1

       o      Tomo:
              For  the  Tomo modality the costs, radiation doses per bi-rad category, sensitivity
              probabilities per bi-rad category, and specificity  probabilities  for  age  groups
              must be specified.
              The default configuration file contains the following Tomo specifications:

                  Tomo:
                      costs:         64

                      #      bi-rad:  a       b       c       d
                      dose:           3       3       3       3
                      sensitivity:    .87     .84     .73     .65

                      #             ageGroup
                      specificity:  0 - 40:  .961     40 - *: .965

       o      MRI:
              For  the  MRI modality the costs, and the sensitivity and specificity probabilities
              must be specified.
              The default configuration  file  contains  (below  the  line  MRI:)  the  following
              specifications:

                      costs:          280
                      #               proportion
                      sensitivity:      .94
                      specificity:      .95

Section `Screening:’

       This  section  starts  with  a line containing Screening: and it defines the ages at which
       screenings are performed, the used screening modality/modalities  for  each  of  the  used
       screening  ages,  and  contains the the screenings attendance probability. If no screening
       rounds should be used then specify a single round-specification line:

           round: none

       Otherwise, each screening round is defined by the keyword round: followed by an age, which
       in  turn  is  followed  by  a list of at least one space delimited modality specification.
       Currently Mammo, Tomo, MRI and CT are available. Mammo, Tomo, and  MRI  can  be  specified
       when performing breast-cancer simulations, CT can be specified when performing lung-cancer
       simulations. The default configuration file contains the  Screening:  specifications  also
       used in versions before 15.00.00:

           round:     50  Mammo
           round:     52  Mammo
           round:     54  Mammo
           round:     56  Mammo
           round:     58  Mammo
           round:     60  Mammo
           round:     62  Mammo
           round:     64  Mammo
           round:     66  Mammo
           round:     68  Mammo
           round:     70  Mammo
           round:     72  Mammo
           round:     74  Mammo

       For  lung  cancer  simulations  the  CT  modality must be specified, either in an analysis
       specification or by altering the configuration file. E.g.,

       Screening:
           round:     50  CT
           round:     52  CT
           round:     54  CT
           round:     56  CT
           round:     58  CT
           round:     60  CT
           round:     62  CT
           round:     64  CT
           round:     66  CT
           round:     68  CT
           round:     70  CT
           round:     72  CT
           round:     74  CT

           #                   probability:
           attendanceRate:     .8

Section `Tumor:’

       This section starts with a line containing Tumor: and it defines the parameters specifying
       tumor  characteristics.  Several  of  the  parameters  in  this  section  can be varied by
       specifying spread: true in the section Scenario:, in which case statistical variations are
       applied to these parameters.

       Supported  distributions  are  Normal,  Uniform, LogNormal, and (for the lung-cancer Beir7
       parameters) the Beta distribution . If value is the specified value parameter  value,  and
       spread  the  specified  spread parameter then the values that are actually used during the
       simulations are:

       o      when using the Normal distribution N(mean, stddev):
                 N(value, spread)

       o      when using the Uniform distribution U(begin, end):
                 U(value - spread / 2, value + spread / 2)

       o      when using the LogNormal distribution L(mean, stddev):
                 L(value, spread)

       o      the Beta distribution is used when lung cancer simulations are performed. For  male
              cases  the 95% confidence intervals for the beta parameters ranges from .15 to .70,
              for female cases  it  ranges  from  .94  to  2.10,  and  values  drawn  from  these
              distributions  are used when spread: true has been specified (see also section BETA
              DISTRIBUTIONS).

       The spread parameters may not be negative. If spread  values  are  configured  then  their
       distributions  must  also  be  specified.   If  spread  is  not  specified, then the value
       parameter won’t vary if spread: true is specified in the Scenario section. The same  holds
       true  for  the  Beta  distribution: if no spreading should be applied, even though spread:
       true was specified, then the Beta distribution’s specificatins should be omitted.

       The Tumor: section has four subsections: Beir7:, Growth, Incidence:, Survival:,  and  S3:.
       They contain the following parameter specifications:

       Beir7:

       BEIR  (tumor induction) parameters: only tumor induction type 7 (i.e., beir7) is used. The
       default configuration file contains specifications for breast cancer simulations  and  for
       male and female lung cancer simulations:

               #    eta   beta  spread   dist.
           breast:  -2.0   0.51   0.32  Normal

           #                            Beta-distribution parameters:
           # LC:    eta   beta  dist    constant factor   aParam    bParam
           male:    -1.4   .32  Beta    .234091  1.72727  2.664237  5.184883
           female:  -1.4  1.40  Beta    .744828   .818966 3.366115  4.813548

       If  spread:  true is specified then the actually used beta parameters are drawn from their
       respective distributions.

       See also National Research Council. 2006. Health Risks from  Exposure  to  Low  Levels  of
       Ionizing  Radiation:  BEIR  VII  Phase  2.  Washington,  DC:  The National Academies Press
       (https://doi.org/10.17226/11340).

       Growth:

       Tumor growth specifications  consist  of  three  elements:  start  diameters,  self-detect
       parameterss and doubling time specifications.

       The  start parameters define the start diameter of emerging tumors used with respectively,
       breast and lung cancer simulations . The default configuration file specifies

               #  breast   lung
           start:    5       3

       The default configuration file contains these specifications of the self-detect parameters
       for breast and lung cancer simulations:

           #selfDetect:      # stdev       mean    spread  dist
           breast:             .70         2.92    .084    Normal
           lung:               .014        3.037   .61     Normal

       Four  parameters  are  used to determine the diameter at which self-detection is possible.
       These parameters are:

       o      the standard deviation (stdev) used by the lognormal distribution  to  compute  the
              diameter  at  which self-detection occurs. This parameter is required and cannot be
              negative;

       o      the mean (see below) used by the lognormal distribution. This parameter is required
              and  cannot  be negative. Its value will vary using the following two parameters if
              spread: true was specified;

       o      the spread (standard deviation) used by the distribution that is used to  vary  the
              mean  if spread: true was specified. It can be omitted in which case the mean won’t
              vary;

       o      the distribution used to vary the mean. If the previous parameter is  omitted  then
              this parameter must also be omitted.

       The actually used self-detect diameter is computed using:

           diameter = L(mean, stdev)

       Finally,  the  Growth: subsection also defines tumor doubling times for various age groups
       when using breast cancer simulations and for all ages when using lung cancer simulations.

       Doubling times  are  computed  like  the  self-detect  diameters,  i.e.,  using  lognormal
       distributions. Thus, for each age group and for the lung cancer simulation four parameters
       are specified (of which the final  two  are  optional):  the  standard  deviation  of  the
       lognormal  distribution,  the mean value of the lognormal distribution, and the spread and
       name of the distribution that is used when spread: true was specified.

       The age groups (used with breast cancer simulations) must cover ages 0 through the maximum
       age  for  simulated cases, and are specified as described at section BreastDensities:. The
       default configuration file contains the following specifications:

           DoublingTime:
               #                   stdev   mean  spread  dist.
               ageGroup:  1 - 50    .61    4.38   .43    Normal
               ageGroup: 50 - 70    .26    5.06   .17    Normal
               ageGroup: 70 - *     .45    5.24   .23    Normal

               #     all ages      stdev   mean  spread  dist.
               lung:                .21    4.59   .74    Normal

       Incidence:

       For breast cancer simulations three carrier types are supported: Normal, BRCA1 and  BRCA2.
       Each  having  a probability of occurrence. The probabilities of these carriers must add to
       1. In the default configuration file BRCA1 and BRCA2 are specified, but their probabilties
       are  set  to  0, in which case their specifications can also be removed from configuration
       files.

       Each carrier is identified by  name  (i.e.,  when  performing  breast  cancer  simulations
       Breast:,  BRCA1:,  and  BRCA2; when performing lung cancer simulations: Male: and Female:)
       followed by their parameter specifications:

       o      for breast cancer simulations: the probability that the carrier is observed;

       o      the lifetime risk: three parameters specifying a probability;

       o      the mean age: three parameters specifying the mean age,;

       o      the standard deviation used when computing the risk of getting  a  tumor.  As  this
              standard deviation is used in the denominator of expressions it must be larger than
              zero.

       The lifetime risk, mean age and standard deviation parameters may optionally  be  followed
       by  the  standard  deviation  (spread)  and distribution used to vary the probability when
       spread: true is specified;

       The default configuration file contains these specifications:

       Incidence:
           Male:
               #                   value   spread  distr.
               lifetimeRisk:         .22   .005    Normal
               meanAge:            72.48  1.08     Normal
               stdDev:              9.28  1.62     Normal

           Female:
               #                   value   spread  distr.
               lifetimeRisk:         .20   .004    Normal
               meanAge:            69.62  1.49     Normal
               stdDev:              9.73  1.83     Normal

           Breast:
               probability:    1
               #                   value   spread  distr.
               lifetimeRisk:         .226  .0053   Normal
               meanAge:            72.9    .552    Normal
               stdDev:             21.1

           BRCA1:
               probability:    0
               #                   value   spread  distr.
               lifetimeRisk:         .96
               meanAge:            53.9
               stdDev:             16.51

            BRCA2:
               probability:    0
               #                   value   spread  distr.
               lifetimeRisk:         .96
               meanAge:            53.9
               stdDev:             16.51

       Survival:

       For breast cancer simulations four types of survival parameters must  be  specified.  Each
       type  (a..d)  specifies a mean, and (optionally) a spread and distribution (which are used
       when spread: true has been specified). The default configuration file specifies:

       Survival:
           #              value        spread      dist:
           type:  a        .00004475   .000004392  Normal
           type:  b       1.85867      .0420       Normal
           type:  c       -.271        .0101       Normal
           type:  d       2.0167       .0366       Normal

       For lung cancer simulations table S4 is used to determine the a..d  parameters.  Table  S4
       contains four categories (lung0..lung3) defining these a..d parameters, where (for a known
       cancer’s diameter) the category is randomly determined using table S3 (see below).

       Table S4 is appended to the breast cancer specifications. The default  configuration  file
       contains the following specifications of table S4:

          # table S4: 4 columns per a..d parameter
          # lungX: X is table S4’s column index
          lung0: a        .00143      .00095      Normal
          lung0: b       1.84559      .33748      Normal
          lung0: c       -.22794      .07823      Normal
          lung0: d       1.06799      .16226      Normal

          lung1: a        .01530      .00381      Normal
          lung1: b       1.69434      .10979      Normal
          lung1: c       -.19358      .02105      Normal
          lung1: d        .66690      .03869      Normal

          lung2: a        .78600      .29815      Normal
          lung2: b        .69791      .05425      Normal
          lung2: c        .0          .0          Normal
          lung2: d        .0          .0          Normal

          lung3: a       1.25148      .32305      Normal
          lung3: b        .77852      .34149      Normal
          lung3: c        .0          .0          Normal
          lung3: d        .0          .0          Normal

       S3:

       With  lung  cancer  specifications  tables  S3  and  S4 are used to determine the survival
       parameters. The tumor’s diameter determines the row of table S3, and then  its  column  is
       randomly  determined  using  the  probabilities  listed  in  S3’s  rows.  For each row the
       probabilities must sum to 1. Once the S3 column has been determined the column index which
       of  the  lungX: specifications is used. The row and column indices are 0-based. E.g., if a
       tumor diameter is 24, then row 2 (diameter <= 30) is selected. Then, if the  random  value
       is  .630,  column  1 is used (column N1-3,M0).  Whenever a tumor is present these pairs of
       indices are reported in the comma-separated data file in the column marked as  TNM,  using
       an entry like 2,1.

       The default configuration file contains the following table S3:

           S3:
              #      diameter (mm)
              # T-row    <=       N0,M0   N1-3,M0   N1-3,M1a-b   N0-3M1c
              prob:      10:       .756    .157      .048        .039       # T1a,b
              prob:      20:       .703    .197      .055        .045       # T1b
              prob:      30:       .559    .267      .095        .078       # T1c
              prob:      50:       .345    .351      .167        .137       # T2a,b
              prob:      70:       .196    .408      .218        .178       # T3
              prob:       *:       .187    .347      .256        .210       # T4

       (cf.   https://www.sciencedirect.com/science/article/pii/S2667005421000491  and Table 1 of
       its appendix: https://ars.els-cdn.com/content/image/1-s2.0-S2667005421000491-mmc1.pdf)

       bc:

       When performing breast cancer simulations TNM indices  (cf.  the  description  of  the  S3
       table) are also determined. Here the second TNM value is always 0, and the first TNM value
       is, as with table S3, determined by the tumor’s diameter. The default  configuration  file
       contains the following bc: specification:

           #  BC TNM categories thru (<=) diameters (mm):
           bc:        20  50   *
           #  TNM:    T1  T2  T3

       (cf.
       https://www.cancerresearchuk.org/about-cancer/breast-cancer/stages-types-grades/tnm-staging).

       (see also option --tnm).

BETA DISTRIBUTIONS

       Values    generated    from    Beta   distributions   range   between   0   and   1   (cf.
       https://en.wikipedia.org/wiki/Beta_distribution). The Beta distribution is computed  using
       two                      Gamma                      distributions                     (cf.
       https://www.fmrib.ox.ac.uk/datasets/techrep/tr03tb1/tr03tb1/node24.html,
       https://stats.stackexchange.com/questions/502146/how-does-numpy-generate-samples-from-a-beta-distribution):

           gamma1 = Gamma(aParam, 1)
           Beta(aParam, bParam) = gamma1 / (gamma1 + Gamma(bParam, 1))

       When using lung cancer simulations the 95% confidence interval (CI) for male cases  ranges
       from  .15  to .70, with a mean value of .32, and for women ranging from .94 to 2.10 with a
       mean value of 1.40.

       The male and female CI ranges  are  transformed  to  .025  to  .975  ranges  using  linear
       transformations.  To  transform values x from the male range to the .025 to .975 range the
       transformation y = 1.72727 * x - .234091 is used, and to transform back the transformation
       (y  + .234091) / 1.72727 is used.  For the female CI the transformations are y = .818966 *
       x - .744828 and (y + .744828) / .818966.

       The aParam and bParam values are determined by first generating 1000 values so that  their
       CI  span  the  range  0.025  to  .975,  with a mean value of 0.318635 (for male cases) and
       0.401724 (for female cases). Next the parameters of the  corresponding  beta  distribution
       were estimated using maximum likelihood fitting, resulting in aParam = 2.664237 and bParam
       = 5.184883 for the distribution used  with  male  lungcancer  simulations,  and  aParam  =
       3.366115  and  bParam  =  4.813548  for  the  distribution  used  with  female  lungcancer
       simulations.

       The default configuration file shows these values at the Beir7 beta parameters.

PARAMETER RESPECIFICATION

       Parameters can be respecified by defining a separate parameter configuration  file  or  by
       providing  alternate parameter specifications in Analysis: sections of the program’s input
       file, or by providing alternative parameter specifications as command-line arguments  (cf.
       the simrisc(1) man-page)

FILES

       o      ~/.config/simrisc: the default location of the program’s configuration file;

       o      the  simrisc  distribution  archive  contains  the  default  configuration  file as
              simrisc-VERSION/stdconfig/simrisc, where VERSION is replaced  by  simrisc’s  actual
              release version;

       o      when  installing  simrisc  using Linux distribution archives (e.g., .deb files) the
              default      configuration      file      is      commonly       available       as
              /usr/shared/doc/simrisc/simrisc.gz

SEE ALSO

       simrisc(1)

BUGS

       Versions  before  version 15.03.00 should not be used for lung cancer simulations. The bug
       invalidating lung cancer simulations was repaired in version 15.03.00.

COPYRIGHT

       This is free software, distributed under the terms  of  the  GNU  General  Public  License
       (GPL).

AUTHOR

       Frank B. Brokken (f.b.brokken@rug.nl),