NAME

       bali-phy - Bayesian Inference of Alignment and Phylogeny

SYNOPSIS

       bali-phy sequence-file1 [sequence-file2 ...]  [OPTIONS]

       bali-phy help topic

DESCRIPTION

       bali-phy  estimates  multiple  sequence  alignments and evolutionary trees from DNA, amino
       acid,  or  codon  sequences.   BAli-Phy  uses  MCMC  and  Bayesian  methods  to   estimate
       evolutionary   trees,   positive  selection,  and  branch  lengths  while  averaging  over
       alternative alignments.

       BAli-Phy can also estimate phylogenies from a fixed alignment  (like  MrBayes  and  BEAST)
       using substitution models like GTR+gamma.  BAli-Phy automatically estimates relative rates
       for each gene.

GENERAL OPTIONS

       For each option below, more information is available by specifying the long  form  of  the
       option as a help topic.  For example: bali-phy help alphabet

       -h, –help, –help=topic
              Display a friendly help message.  Specify –help=advanced or –help=expert to display
              more advanced options.

       -v, –version
              Print version information.

       -t, –test
              Analyze the initial values and exit.

       -V, –verbose, –verbose NUM
              Print extra output to aid in trouble-shooting.  If NUM is not specified the default
              is 1.  Values from 2 to 4 increase the amount of information displayed.

       -c filename, –config filename
              Read commands from filename before command line.

MCMC OPTIONS

       -i NUM, –iterations NUM
              The number of iterations to run.

       -n STRING, –name STRING
              Name for the output directory to create.

       -x NUM, –subsample NUM
              Factor by which to subsample.  This option should usually not be used.

       -s NUM, –seed NUM
              Random seed.  Useful for replaying specific runs when trouble-shooting.

PARAMETER OPTIONS

       -T filename, –tree filename
              File with initial tree in Newick format or NEXUS format.

       -U, –unalign
              Unalign  all  variable-alignment  partitions before starting MCMC instead using the
              supplied alignment as a starting value.

MODEL OPTIONS

       -A alphabet, –alphabet alphabet
              The alphabet.

       -S model, –smodel model
              The substitution model.

       -I model, –imodel model
              The insertion-deletion model.

       -B prior, –branch-lengths prior
              Prior on branch lengths.

       -R prior, –scale prior
              Prior on the scale.

       -L NUMS, –link NUMS
              Link partitions.  Takes a comma-separated list of  numbers  indicating  partitions.
              For example --link 1,2,3.

EXAMPLES

       bali-phy dna.fasta --smodel gtr
              Analyze sequences in dna.fasta under the GTR model.

       bali-phy dna.fasta -S gtr -I none
              Perform a traditional fixed-alignment analysis with gaps treated as missing data.

       bali-phy dna.fasta amino.fasta codons.fasta -S 1:gtr -S 2:lg08 -S 3:gy94
              Perform  an  analysis of 3 genes where each gene has a different substitution mode.
              The sequence names in all three files must be the same.

REPORTING BUGS

       BAli-Phy online help: <http://www.bali-phy.org/docs.php>.

       Please send bug reports to <bali-phy-users@googlegroups.com>.

SEE ALSO

       bp-analyze

AUTHORS

       Benjamin Redelings.

                                             Feb 2018                                 bali-phy(1)