NAME

       mssstest - Normalisationo of disease scores - originally developed for the EDSS for Multiple Sclerosis

SYNOPSIS

       mssstest

DESCRIPTION

       Suppose  one is interested in determining whether the genotype at some locus of interest affects the rate
       of progression of disease of people with Multiple Sclerosis (MS). One method would be  to  calculate  the
       mean EDSS score in patients with each of the genotypes and test whether they are significantly different.
       However, this approach is inefficient if patients have their EDSS  assessed  at  different  durations  of
       disease,  as  patients  who  have  had  MS  longer  typically have higher EDSS scores regardless of their
       genotype. By adjusting for duration, a more powerful test can be developed.
       MSSStest is a program for implementing the  method  described  in  the  article  The  Multiple  Sclerosis
       Severity Score. R. Roxburgh S. Seaman et al. (2004), accepted for publication by Neurology. It calculates
       MSSS scores and uses these scores to test for differences between disease progression rates in  different
       groups defined by genotype at some locus.
       To  use  the program first copy the table of disease scores to the current directory. You are expected to
       use the EDSS scores provided by the authors.

OPTIONS

       The program does not accept options, it should, though. The output  goes  to  the  files  "msss.out"  and
       "indivmsss.out".

SEE ALSO

       http://www-gene.cimr.cam.ac.uk/MSgenetics/GAMES/MSSS/#top
       /usr/share/doc/mssstest/README.gz

AUTHOR

       mssstest was written by Shaun Seaman and Richard Roxburgh <Richard@Roxburgh.net.nz>.

       This manual page was written by Steffen Moeller <moeller@pzr.uni-rostock.de>, for the Debian project (but
       may be used by others).

                                                November 30, 2004                                    MSSSTEST(1)